BIOGRAPHICAL
SKETCH
Provide the following
information for the key personnel in the order listed on Form Page
2.
Follow the sample format for each person. DO NOT EXCEED
FOUR PAGES.
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NAME
Louis Robert Pasquale,
MD. |
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POSITION
TITLE
Co-Director,
Glaucoma Service, MEEI
Research Director, Ocular
TeleHeealth Ctr, Boston VA Hosp.
Assistant Professor of
Ophthalmology, Harvard Medical School
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| EDUCATION/TRAINING
(Begin with baccalaureate or other initial professional
education, such as nursing, and include postdoctoral
training.) |
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INSTITUTION AND
LOCATION
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DEGREE
(if applicable) |
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YEAR(s)
(if
applicable) |
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FIELD OF
STUDY
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Manhattan College,
New York, New York
State University of New York, Stony
Brook, NY
Bronx Municipal Hosp./Albert Einstein Coll. of
Medicine,...
Temple University Hospital, Philadephia,
PA.
Johns Hopkins University Hospital, Baltimore,
MD.
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B.S.
M.D.
Internship
Residency
Fellowship
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1982
1986
1987
1990
1992
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BIochemistry
Medicine
Internal
Medicine
Ophthalmology
Glaucoma
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| A. Positions and
Honors.
Positions
and Employment
| 1990-1992 |
Glaucoma Fellow,
Johns Hopkins U. Hosp., Balt., MD. |
| 1992 |
Associate Surgeon,
Brigham and Women's Hosp., Boston, MA. |
| 1992 |
Consultant, Joslin
Diabetes Center, Boston, MA. |
| 1992-2000 |
Instructor in
Ophthalmology, Harvard Med. Sch., Boston, MA |
| 1994 |
Attending, Boston
VA Hospital, Jamaica Plain, MA. |
| 1995-2003 |
Consultant,
Children's Hospital, Boston, MA. |
| 1996 |
Assist. Surgeon,
Mass. Eye & Ear Infirmary, Boston, MA. |
| 1997 |
Consultant in
Surgery, Beth Israel Deaconess Medical Ctr, Boston,
MA. |
| 2000 |
Assist. Prof. of
Ophthalmology, Harvard Med. Sch., Boston, MA |
| 2003 |
Clinical Assistant
Scientist, Schepens Eye Research Institute, Boston,
MA. |
Other
Experience and Professional
Memberships
| 1993 |
Volunteer, Health
Task Force, The White House, Washington, D.C., |
| 2000 |
Member, Fellowship
Committee, Massachusetts Eye and Ear Infirmary, |
| 2000 |
Member, OR
Committee, Massachusetts Eye and Ear Infirmary, |
| 2002 |
Co-Chair, Glaucoma
Specialty Clinical Update, Am. Academy of
Ophthalmology |
| 2002 |
Member, Human
Subject Committee, Massachusetts Eye and Ear
Infirmary |
| 2002-2004 |
Chairperson/Ophthal.
Perf., Quality Council Committee, Mass. Eye &
Ear... |
| 2003 |
Board of
Directors, Mass. Eye & Ear Infirmary & Physicians
Staff; Mass. Eye &... |
| 2004 |
Ad-Hoc Reviewer,
Glaucoma Knowledge Base Panel, Am. Academy of
Ophthalmol. |
| 2004 |
Member, Continuing
Medical Education, Harvard Medical School, HMS /
HSDM |
Honors
| 1981 |
Sigma Xi,
Manhattan College |
| 1982 |
Phi Beta Kappa,
Manhattan College |
| 1982 |
Summa Cum Laude,
Manhattan College |
| 1985 |
Alpha Omega Alpha,
SUNY Stony Brook |
| 1990 |
Distinguished
Research Award, Department of Ophthalmology, Temple University
Hospital |
| 1991 |
Heed Ophthalmic
Fellowship, Heed Foundation |
| 1995 |
Harvard Medical
School Award for Mentoring; Nominee, Harvard Medical
School |
| 2003 |
Recognition for
outstanding teaching & commitment to education by
ophthalmology residents,
MEEI | |
B. Selected
peer-reviewed publications (in chronological order).
| 1. |
DiToro DM, Mahony
J, Kirchgraber P, O'Byrne AL, Pasquale LR, Piccirilli D.
Effects of nonreversibility, particle concentration and ionic
strength on heavy metal sorption. Env Sci & Tech.
1986;20:55-61. |
| 2. |
Pasquale LR,
Winiski A, Olivia C, Vaio G, Mclaughlin S. An experimental
test for the eletrokinetic properties of biological membranes.
J Gen Physiol. 1986;88:697-718. |
| 3. |
Pasquale LR,
Moster ML, Schmaier A. Dural sinus thrombosis with
abnormalities of protein S and fibrinogen. Arch Ophthalmol.
1990;108:644. |
| 4. |
Pasquale LR,
Mathias RT, Austin L, Brink PR, Ciunga M. The eletrostatic
properties of fiber cell membranes from the frog lens. Biophys
J. 1990;58:939-45. |
| 5. |
Pasquale LR,
Romayananda N, Kubacki J, Johnson M, Chan GH. Congenital
cystic eye with multiple ocular and intracranial
abonormalities. Arch Ophthal. 1991;109:985-87. |
| 6. |
Pasquale LR, Smith
SG, Traboulsi E, Jampel H. Spontaneous filtering blebs in a
patient wiht microspherophakia. Am J Ophthalmol.
1991;112:350-2. |
| 7. |
Derick RJ,
Pasquale LR, Quigley HA, Jampel HD. Potential toxicity of
mitomycin C. Arch Ophthal. 1991;109:1635. |
| 8. |
Pasquale LR,
Thibault D, Dorman-Pease ME, Quigley HA, Jampel HD. Effect of
topical mitomycin C on glaucoma filtration surgery in monkeys.
Ophthalmology. 1992;99:14-8. |
| 9. |
Jampel HD,
Pasquale LR, DiBernardo C. Hypotony maculopathy after
trabeculectomy with mitomycin C. Arch Ophthalmology.
1992;110:1049-50. |
| 10. |
Pasquale LR, Smith
SG. Surgical outcome of phacoemulsification combined with the
Pearce trabeculectomy in patients with glaucoma. J Cat and
Refr Surgery. 1992;18:301-5. |
| 11. |
Pasquale LR,
Dorman-Pease ME, Lutty GA, Quigley HQ, Jampel HD.
Immunolocalization of TGF-B1, TGF-B2 and TGF-B3 in the
anterior segment of the human eye. Invest Ophthalmol Vis
Science. 1993;34:23-30. |
| 12. |
Aiello LP, Avery
RL, Arrigg PG, Keyt B, Jampel HD, Shah ST, Pasquale LR, Thieme
H, Iwamoto MA, Park JE, Nguyen H, Aiello LM, Ferrara N, King
GL. Vascular endothelial growth factor in ocular fluids of
patients with diabetic retinopathy and other retinal
disorders. New Engl J Med. 1994;331:1480-1487. |
| 13. |
Derick RJ Pasquale
LR, Dorman-Pease ME, Quigley HA. A clinical study of
peripapillary crescents of the optic disc in chronic
experimental glaucoma in monkey eyes. Arch Ophthalmol.
1994;112:846-850. |
| 14. |
Norlund JR,
Pasquale LR, Robin AL, Rudikoff MT, Ordman J, Chen KS, Walt J.
The cardiovsascular, pulmonary, and ocular hypotensive effects
of 0.2% brimonidine tartrate. Arch Ophthamol. 1995;113:77-83.
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| 15. |
VanderVeen DK,
Pasquale LR, Fulton AB. Central retinal vein occlusion in a
young child with cyanotic heart disease. Arch Ophthalmol.
1997;115:1077. |
| 16. |
Gasch AT, Wang P,
Pasquale LR. Determinants of glaucoma wareness in a general
eye clinic. Ophthalmology. 2000;107:303-308. |
| 17. |
Bohn RL, Gurwitz
JH, Yeomans SM, Glynn RJ, Pasquale LR, Walker AM, Avorn J.
Which patients are treated for glaucoma? An observational
analysis. J of Glaucoma. 2000;9:38-44. |
| 18. |
Chen TC, Ang RT,
Grosskreutz CL, Pasqale LR, Fan JT. Brimonidine 0.2% versus
apraclonidine 0.5% for prevention of rise in intraocular
pressure following anterior segment laser surgery.
Ophthalmology. 2001;108:1033-1038. |
| 19. |
Sankar PS,
Pasquale LR, Grosskreutz CL. Uveal effusion and secondary
angle-closure glaucoma associated with Topiramate use. Arch of
Ophthal. 2001;119:1210-11. |
| 20. |
Kang JH, Pasquale
LR, Rosner B, Willet W, Faberowski N, Hankinson SE.
Prospective study of antioxidant intake and the risk of
primary open-angle glaucoma in two cohorts. Am Journal of
Epidemiology. 2003;158:337-346. |
| 21. |
Faye A, Lee L,
Pasquale LR. Dermatochalasis causing apparent bitemporal
hemianopsia. Ophthal Plast Reconstr Surg. 2003;19:151-3.
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| 22. |
Banks MC,
Robe-Collignon NJ, Rizzo JF, Pasquale LR. Scanning laser
polarimetry of edematous and atrophic optic nerve heads. Arch
Ophthalmol. 2003;121:484-490. |
| 23. |
Kang JH, Pasquale
LR, Rosner B, Willet W, Egan KM, Faberowski N, Hankinson SE.
Prospective study of cigarette smoking and the risk of primary
open-angle glaucoma. Arch Ophthalmol. 2003;121:1762-68.
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| 24. |
Zhao JC, Zacks DN,
Gragoudas ES, Pasquale LR. Pupil-sparing excision of an
atypical iris melanocytoma induces remission of secondary
glaucoma. Br J Ophthalmol. 2004;88:842-3. |
| 25. |
Kang JH, Pasquale
LR, Rosner B, Willet W, Faberowski N, Hankinson SE. Dietary
fat consumption and primary open-angle glaucoma in two
cohorts. Am J Clin Nutr. 2004;79:755-64. |
| 26. |
Brauner SC, Chen
TC, Chang MA, Pasquale LR, Grosskreutz CL. Glaucoma during
pregnancy. Ophthalmology (submitted). 2005. |
| 27. |
Geiser DK,
Williams RT, O’Connell W, Dul M, Pasquale LR, Watt JG, Katz
LM, Siegartel LR, Wang L, Stern LS, Doyle JJ. Cost and
utilization of end-stage glaucoma patients receiving low
vision rehabilitation care: A U.S. multi-site retrospective
study. J of Glaucoma (submitted). 2005. |
| 28. |
Pasquale LR,
Brusie S, Pahk P, Fine L, Grosskreutz CL, Chen T, Winkelmeyer
W. The blue arc phenomenon in glaucoma. Br J Ophth-in
preparation. 2005.
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| C. Research
Support.
Ongoing
Research Support
| Louis R. Pasquale,
M.D. |
1/1/2002
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D.O.D.
Diabetes
and Glaucoma Detection Project
The major goals of this
project are to investigate the use of telemedicine to improve
screening for diabetic retinopathy and glaucoma
Role:
Co-P.I. |
| Louis R. Pasquale,
M.D. |
1/1/2005
- 1/1/10 |
N.I.H.
Gene-environment
in glaucoma interactions
The goal of research is discover
novel gene-environment interaction terms associated with
primary open-angle glaucoma
Role: P.I.
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Completed
Research Support
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01/01/00
- 12/31/05 |
N.I.H.
Prospective
Study of Risk Factors for Eye Disease
The primary aim of
this study is to investigate lifestyle and genetic risk
factors in relation to age-related macular degeneration and
primary open angle glaucoma in two prospectively followed
cohorts of men and women. The study will evaluate the dietary
intake of antioxidants, postmenopausal hormone use, and
variants in the ATP-binding cassette-transport retina gene in
relation to both wet and dry age-related macular degeneration,
and antioxidant intake, smoking, and systemic blood pressure
in relation to primary open angle glaucoma (POAG).
Role:
Co-P.I. |
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5/1/2004
– 2/31/2005 |
Herman Eye Center
Travaprost Additivity Study
The major goal of this
study is to compare the efficacy and safety of travaprost plus
brimonidine versus travaprost plus brinzolamide in the
treatment of open-angle glaucoma. This is a prospective,
multicentered, randomized clinical trial that enrolled 216
patients nationwide.
Role: P.I.
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