Curriculum Vitae

CURRICULUM VITAE

DATE PREPARED: November 4, 2005

PART I: General Information

Name:	Louis Robert Pasquale, MD.




Office Address:	Massachusetts Eye and Ear Infimary Glaucoma Service 243 Charles Street Boston, MA 02114 United States
Phone:	(617) 523-7900
Email:	Louis_Pasquale@meei.harvard.edu
Fax:	(617) 573-3707

Place of Birth:

New York, New York

Education:

	1982	B.S. (Biochemistry), Summa cum laude, Manhattan College
	1986	M.D. Distinction in Resch, Alpha Omega Alpha, SUNY, Stony Brook

Postdoctoral Training:

	1986-1987	Intern in Medicine, Internal Medicine, Bronx Municipal Hospital/Albert Einstein College of Mediciine
	1987-1990	Resident in Ophthalmology, Ophthalmology, Temple University Hospital
	1990-1992	Fellow in Glaucoma, Glaucoma, Johns Hopkins University Hospital/Wilmer Ophthalmological Institute

Licensure and Certification:

	1988	Pennsylvania Registered Physician
	1990	Maryland Registered Physician
	1991	American Board of Ophthalmology-Lifetime certification
	1992	Massachusetts Registered Physician

Academic Appointments:

	1990-1992	Assistant in Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD.
	1992-2000	Instructor in Ophthalmology, Harvard Medical School, Boston, MA
	2000-	Assistant Professor of Ophthalmology, Harvard Medical School, Boston, MA

Hospital or Affiliated Institution Appointments:

	1990-1992	Clinical and Research Fellow in Glaucoma, Johns Hopkins University Hospital, Baltimore, MD.
	1992-	Associate Surgeon, Brigham and Women's Hospital, Boston, MA.
	1994-	Consultant in Glaucoma, V.A. Hospitals, other, Jamaica Plain, MA.
	1994-	Consultant in Glaucoma, Joslin Diabetes Center/Beetham Eye Institute, Boston, MA.
	1995-2003	Consultant in Glaucoma, Children's Hospital, Boston, MA.
	1996-	Assistant Surgeon, Massachusetts Eye and Ear Infirmary, Boston, MA.
	1997-	Consultant in Surgery, Beth Israel Deaconess Medical Center, Boston, MA.
	2003-	Clinical Assistant Scientist, Schepens Eye Research Institute, Boston, MA.

Hospital and Health Care Organization Clinical Service Responsibilities:

	1992-2003	Attending Physician in Ophthalmology, Brigham and Women's Hospital
	1994-	Glaucoma Consultant, V.A. Hospitals, other
	1994-	Attending Physician in Ophthalmology, Beth Israel Deaconess Medical Center (West)
	1994-	Glaucoma Consultant, Joslin Diabetes Center/Beetham Eye Institute
	1995-2003	Glaucoma Consultant, Children's Hospital
	1996-	Attending Physician in Ophthalmology, Massachusetts Eye and Ear Infirmary

Major Administrative Responsibilities:

	1992-2003	Director, Glaucoma Service, Brigham and Women's Hospital
	1995-1996	Director, Anterior Segment Fellowship, Brigham and Women's Hospital
	1998-	Director, Glaucoma Fellowship Program, Massachusetts Eye and Ear Infirmary
	1998-	Co-Director, Glaucoma Service, Massachusetts Eye and Ear Infirmary
	2004-	Research Director, Ocular TeleHealth Center, V.A. Hospitals, other

Major Committee Assignments:

	1993	Health Task Force, Volunteer, The White House, Washington, D.C.
	2000-	OR Committee, Member, Massachusetts Eye and Ear Infirmary
	2000-	Fellowship Committee, Member, Massachusetts Eye and Ear Infirmary
	2002-	Human Subject Committee, Member, Massachusetts Eye and Ear Infirmary
	2002-2003	Glaucoma Specialty Clinical Update, Co-Chair, American Academy of Ophthalmology
	2002-2004	Quality Council Committee, Chairperson, Massachusetts Eye and Ear Infirmary
	2003-	Massachusetts Eye and Ear Infirmary & Physicians Staff, Board of Directors, Massachusetts Eye and Ear Infirmary
	2004-	Continuing Medical Education, Member, Harvard Medical School
	2004	Glaucoma Knowledge Base Panel, Ad-Hoc Member, American Academy of Ophthalmology

Professional Societies:

	1986-	Assoc. for Research and Vision in Ophthalmology, Member
	1987-	American Academy of Ophthalmology, Member
	1990-	American Society of Cataract and Refractive Surgery, Member
	1992-	Glaucoma Research Catalyst Program, Charter Member
	1992-	Massachsetts Society of Eye Physicians and Surgeons, Member
	1992-	Friedenwald Glaucoma Society, Member
	1998-	New England Ophthalmological Society, Member
	1999-	American Glaucoma Society, Member
	2005-	Chandler Grant Society, Member

Editorial Boards:

	1990-	Reviewer, Archives of Ophthalmology
	1991-	Reviewer, Ophthalmology
	1992-	Ad-Hoc Reviewer, New England Journal of Medicine
	1992-	Ad-Hoc Reviewer, Journal of Toxicology-Cutaneous and Ocular Toxicology
	1993-	Ad-Hoc Reviewer, Investigative Ophthalmology and Visual Science
	1993-	Ad-Hoc Reviewer, Current Eye Research
	1994-	Ad-Hoc Reviewer, Experimental Eye Research
	1996-	Ad-Hoc Reviewer, Journal of Glaucoma
	1997-	Ad-Hoc Reviewer, Ophthalmic Surgery and Lasers
	1998-	Ad-Hoc Reviewer, Survey of Ophthalmology
	2001-	Ad-Hoc Reviewer, Middle East Journal of Ophthalmology
	2001-	Reviewer, British Journal of Ophthalmology
	2002-	Ad-Hoc Reviewer, Eye
	2002-	Ad-Hoc Reviewer, Digital Journal of Ophthalmology
	2003-	Ad-Hoc Reviewer, Ophthalmic Epidemiology
	2003-	Ad-Hoc Reviewer, Menopause
	2003-	Reviewer, American Journal of Ophthalmology
	2004-	Ad-Hoc Reviewer, Optometry and Vision Research
	2004-	Ad-Hoc Reviewer, Diabetes/Metabolism Research and Reviews

Awards and Honors:

	1981	Sigma Xi, Manhattan College
	1982	Phi Beta Kappa, Manhattan College
	1982	Summa Cum Laude, Manhattan College
	1985	Alpha Omega Alpha, SUNY Stony Brook
	1990	Distinguished Research Award, Department of Ophthalmology, Temple University Hospital
	1991	Heed Ophthalmic Fellowship, Heed Foundation
	1995	Nominee - Award for Mentoring, Harvard Medical School
	2003	Recognition for Outstanding Teaching, Massachusetts Eye and Ear Infirmary

Part II: Research, Teaching, and Clinical Contributions

A. Narrative report of Research, Teaching, and Clinical Contributions

The goal of my research is to achieve “optic neuroprevention” defined as the prevention of functional blindness from glaucoma worldwide. I have two specific aims:
• To detect all previously undiagnosed glaucoma cases. Evidence-based medicine clearly indicates that current treatment modalities slow the progression of the disease such that early detection alone should reduce visual disability particularly from open-angle glaucoma.
•To understand the pathogenesis of POAG, the most common form of glaucoma in the Western world so as to develop more rationale management strategies for the disease since current treatments do not halt the disease
For the first specific aim, I am developing a novel psychophysical test for optic nerve disease that ultimately can be self-administered on the internet. Also, I am involved in validating tele-ophthalmic technologies to detect glaucomatous optic neuropathy. For the second specific aim, I view POAG as a “complex disease” that is dictated by novel interactions between genetic and environmental factors. I collaborate with researchers in various disciplines to seek out these unique, but elusive, disease determinants.

I am actively involved in the medical and surgical training of residents and fellows who rotate through the Glaucoma Service at the Massachusetts Eye and Ear Infirmary. I routinely receive outstanding grades in the continuing education courses I participate in. I am Course Director of a new online initiative to teach primary care providers how to manage cases of the red eye. At the American Academy of Ophthalmology, I will direct a course on using evidence-based medicine to manage glaucoma.

My colleague Dr. Grosskreutz and I described a syndrome of acute myopia and secondary angle closure glaucoma associated with topiramate, an antiseizure drug released in the US in 1998. Our description of the association of this entity with topiramate use prompted the FDA to amend the PDR to include this information.
Patients often ask if lifestyle behaviors modify the natural history of POAG. My colleagues and I found that antioxidant intake and cigarette smoking did not modify the risk of developing POAG. A diet high in n-6 polyunsaturated fats (such as those found in peanut oils) relative to n-3 fats (such as those found in fish oils) was associated with a reduced risk of POAG. While this latter finding does not readily translate into a public health recommendation because of the systemic health benefits of n-3 fat, it does lend insight into the mechanism of the disease. Specifically, the data suggests that one can achieve lower intraocular pressure through a diet that alters intraocular prostaglandin F2 alpha levels.

B. Funding Information

	1990-1992	P.I., N.I.H., T32, The cell biology of glaucoma filtration surgery
	1997-1998	Co-P.I., The Glaucoma Foundation, Antioxidant intake and glaucoma
	2000-2005	Co-P.I., N.I.H., EY09611-08 , Prospective study of dietary risk factors for glaucoma
	2000-2005	P.I., Joint Center for Clinical Research, Retinal autoregulation in normal tension glaucoma
	2001-	P.I., Foundation, The role of the endothelial nitric oxide synthase gene in primary open-angle glaucoma
	2002-	Co-P.I., D.O.D., MIPR9931, The use of nonmydriatic camera to detect glaucoma and other age-related eye disease
	2004-2005	P.I., Herman Eye Fund, HEF - 042 , The travatan additivity study
	2005-2010	P.I., N.I.H., EY015473, Gene-environment interactions in glaucoma

C. Report of Other (Non-Funded) Activities

	P.I.	The blue arc entoptic phenomenon in glaucoma
	P.I.	The GON 10.9 project: long-term visual prognosis in patients with advanced glaucomatous optic neuropathy
	P.I.	Endophenotypic description of glaucoma patients who present with paracentral visual loss

D. Report of Teaching

1. Local contributions

a. Medical School Courses

1999

4th Year Comprehensive Examination

		contact time	prep time
Examiner	6 Medical Students	5 hours/year for 1 year(s)	4 hours/year for 1 year(s)

1999-2004

Introduction to Preventive Medicine

		contact time	prep time
Lecturer	100 Medical Students	2 hours/year for 1 year(s)	30 hours/year for 1 year(s)

2001

4th Year Comprehensive Examination

		contact time	prep time
Examiner	6 Medical Students	5 hours/year for 1 year(s)	4 hours/year for 1 year(s)

2004

Ophthalmology Elective for 4th Year Medical Students

		contact time	prep time
Lecturer	6 Medical Students	15 hours/year for 1 year(s)	30 hours/year for 1 year(s)

b. Graduate Medical Courses

1994

Harvard Ophthalmology Review Course

		contact time	prep time
Lecturer	20 Resident 55 Other Students	4 hours/year for 1 year(s)	8 hours/year for 1 year(s)

1997

Osler Ophthalmology Review Course

		contact time	prep time
Lecturer	50 Resident 25 Other Students	4 hours/year for 1 year(s)	8 hours/year for 1 year(s)

1997-2000

Harvard Ophthalmology Review Course

		contact time	prep time
Lecturer	20 Resident 55 Other Students	4 hours/year for 4 year(s)	8 hours/year for 4 year(s)

1998-

The Lancaster Course

		contact time	prep time
Lecturer	60 Resident	12 hours/year for 8 year(s)	40 hours/year for 8 year(s)

2003-

The Biology of Ophthalmic Disease

		contact time	prep time
Lecturer	20 Post-doc Students	1 hours/year for 3 year(s)	20 hours/year for 1 year(s)

	c. Local Invited Presentations

	Grand Rounds

	1998	Quantitative Nerve Fiber Layer Analysis, Massachusetts Eye and Ear Infirmary Lecturer: 50 participants, 1 hours contact time per year, 4 hours prep time per year

	Meeting

	2001	Frequency Doubling Perimetry, New England Ophthalmological Society Lecturer: 50 participants, 1 hours contact time per year, 20 hours prep time per year

	2002	Galucoma in the Setting of Ocular Trauma, New England Ophthalmological Society Lecturer: 100 participants, 1 hours contact time per year, 20 hours prep time per year

	2003	Does this patient have glaucoma? An 8-year old with Stevens Johnson Syndrome, New England Ophthalmological Society Lecturer: 30 participants, 1 hours contact time per year, 10 hours prep time per year

	2004	Ultrasound Biomicroscopy of Ocular Tumors, New England Ophthalmological Society Lecturer: 100 participants, 1 hours contact time per year, 10 hours prep time per year

	Seminar

	1998-2004	The Aging Eye, Brigham and Women's Hospital Lecturer: 10 participants, 1 hours contact time per year, 4 hours prep time per year

	1998-2005	Visual Field Interpretation, Massachusetts Eye and Ear Infirmary Lecturer: 50 participants, 1 hours contact time per year, 3 hours prep time per year

	1998-2005	The Red Eye, Brigham and Women's Hospital Lecturer: 10 participants, 1 hours contact time per year, 2 hours prep time per year

	2004	Glaucoma Management: Drop, Zap, or Chop?, Massachusetts Eye and Ear Infirmary Lecturer: 50 participants, 1 hours contact time per year, 10 hours prep time per year

	d. Continuing Medical Education Courses

	1993	Antimetabolites and Advances in Filtration Surgery Lecturer: 100 participants, 1 hours contact time per year, 4 hours prep time per year

	1993	Glaucoma Dagnosis and Management: New Concepts Conference Leader: 60 participants, 6 hours contact time per year, 40 hours prep time per year Lecturer: 60 participants, 1 hours contact time per year, 6 hours prep time per year

	1993-2004	Office Practice of Primary Care Medicine Lecturer: 75 participants, 3 hours contact time per year, 12 hours prep time per year

	1994	Glaucoma Review Course Lecturer: 60 participants, 1 hours contact time per year, 4 hours prep time per year

	1994-1995	Offfice Practice of Infectious Disease Lecturer: 200 participants, 1 hours contact time per year, 4 hours prep time per year

	1995	Primary Care for Subspecialists: Developing a Knowledge-Base for Primary Care Practice Lecturer: 150 participants, 1 hours contact time per year, 2 hours prep time per year

	1996	Kevin Hill Seminar in Ophthalmology: Glaucoma Lecturer: 50 participants, 6 hours contact time per year, 20 hours prep time per year

	1997-	Pri-Med Course Lecturer: 1500 participants, 2 hours contact time per year, 8 hours prep time per year Course faculty: 1500 participants, 1 hours contact time per year, 4 hours prep time per year

	1997	Ophthalmology Update Course: Pre-American Cataract and Refractive Surgery Meeting Lecturer: 50 participants, 1 hours contact time per year, 4 hours prep time per year

	2001	New Horizons in Glaucoma: New Concepts : 200 participants, 1 hours contact time per year, 16 hours prep time per year

	2003	Breakfeast with the Experts: Secondary Angle-Closure Glaucoma Conference Leader: 8 participants, 1 hours contact time per year, 8 hours prep time per year

	2004	The Red Eye: An Online CME Course Course Director: 100 participants, no contact time reported, 100 hours prep time per year

	2005-	Cape Cod - Innovation in Glaucoma and Anterior Segment Surgery Lecturer: 50 participants, 1 hours contact time per year, 10 hours prep time per year

	2005	Evidence-Based Medicine in the Management of Glaucoma Conference Leader: 0 participants, 1 hours contact time per year, 20 hours prep time per year

	2005	Breakfeast with the Experts: Glaucoma with Paracentral Visual Loss Conference Leader: 8 participants, 1 hours contact time per year, 10 hours prep time per year

	2005-	Continuing Professional Education Fellows Program for Glaucoma Fellows Lecturer: 60 participants, 1 hours contact time per year, 10 hours prep time per year

	2005	56th Annual Post-Graduate Review Course Lecturer: 230 participants, 2 hours contact time per year, 40 hours prep time per year

	e. Advisory and Supervisory Responsibilities in Clinical or Laboratory Setting

	1998-	4 Residents and Fellows for 100 hrs/year, Supervising in Clinic and OR, Massachusetts Eye and Ear Infirmary

	f. Leadership Roles

	1992-2003	Director, Glaucoma Service, Brigham and Women's Hospital Responsibility: Oversee clinical, teaching and research activities Special Accomplishments: I built a large active glaucoma service while forging fruitful collaborations with researchers at the Channing Lab. I also served as glaucoma consultant for difficult cases encountered in other Longwood Medical Area institutions.

	1995-1996	Director, Anterior Segment Fellowship, Brigham and Women's Hospital Responsibility: Recruited and supervised the activities of anterior segment fellows

	1998-	Co-Director, Glaucoma Service, Massachusetts Eye and Ear Infirmary Responsibility: Oversee the clinical, teaching and research activities of the Glaucoma Service. Special Accomplishments: With the support of the Chiefs of Ophthalmology, I helped grow the service from 10000 outpatient visits per year to nearly 20000 outpatient visits per year over a 7-year period. During that time, Dr. Grosskreutz and I converted the service to a 100% full-time staff. We are attracking meaningful industry-sponsored research and now have the most NIH-sponsored grants of any service at MEEI.

	1998-	Director, Glaucoma Fellowship, Massachusetts Eye and Ear Infirmary Responsibility: Recruit, mentor and supervise the clinical and research activities of glaucoma fellows Special Accomplishments: I helped grow the fellowship from a 1 fellow per year to a 2 fellow per year program without diluting the surgical experience for MEEI residents. The fellowship has become one of the most sort-after glaucoma fellowships in the country.

g. Advisees/Trainees

Training Duration	Name	Current Position
1996-1997	Abha Amin, M.D.	Private Practice
1996-1997	Jill Smith, M.D.	Private Practice
1997-1998	Scott Hoffman, MD	Private Practice
1997-1998	Ed Lauenberger, MD	Private Practice
1997-1998	Teresa Chen, M.D.	Assistant Professor
1998-1999	Annabelle Costa, MD	Private Practice
1998-1999	Alice Gasch, MD	Private Practice
1998-1999	Robert Ang, MD	Private Practice
1998-1999	Ignatius C. Cyriac, MD	Private Practice
1999-2000	Nicholas Faberowski, MD	Private Practice
2000-2001	Richard Maw	Private Practice
2000-2001	Prithvi Sankar	Assistant Professor
2001-2002	Lynn Halpern, MD, PhD	Private Practice
2001-2002	David Yi, MD	Private Practice
2001-2002	Lillian Lee, MD	Private Practice
2002-2003	Jason Swanner, MD	Assistant Professor
2002-2003	Laura Fine, MD	Private Practice
2002-2003	Ho Ching Lin, MBBS	Assistant Professor
2003-2004	Douglas Kohl, MD	Private Practice
2003-2004	Jing C. Zhao, MD	Private Practice
2004-2005	Zarmeena Vendal, MD	Private Practice
2004-2005	Jason Wanner, DO	Private Practice

2. Regional, national, or international contributions

	a. Invited Presentations

	Invited Lecture

	National
	1999	Glaucoma Subspecialty Day: Management of Pigmentary Glaucoma, American Academy of Ophthalmology

	2001	Glaucoma Subspecialty Day: Choroidal Effusion and Hemorrhage: What to do and When , American Academy of Ophthalmology

	2003	Management of Glaucoma in the Uveitis Patient, American Uveitis Society

	2004	Glaucoma Subspecialty Day: When do I Need to do a Non-glaucomatous Work-up?, American Academy of Ophthalmology

	2005	Super Bowl of Grand Rounds: An 8-year old with Stevens Johnson Syndrome and Elevated Intraocular Pressure, American Glaucoma Society

	Regional
	1999	Grand Rounds: Nerve Fiber Layer Analysis, Albany Medical College

	1999	Grand Rounds: Normal Tension Glaucoma: FAQ's and the Facts, New York Hospital

	2000	Normal Tension Glaucoma, Illinois Association of Ophthalmology

	2001	Grand Rounds: Complications of Seton Surgery, New York Hospital

	2001	Uveal Effusion and Secondary Angle-Closure Glaucoma Associated with Topiramate Use, New England Ophthalmological Society

	2002	Grand Rounds: Can Evidence-Based Medicine Guide the Choice of Adjunctive Medical Therapy for Glaucoma? , University of Vermont

	2002	Grand Rounds: Thinking Upstream of Vascular and Mechanical Factors: The Pathogenesis of Primary Open-Angle Glaucoma, Yale Universtiy Hospital

	2002	Reintal Vascular Autoregulation and Normal Tension Glaucoma, Southwestern Medical School, Dallas, TX

	2003	Grand Rounds: Disc Hemorrhages: How Important are They in Glaucoma Pathogenesis?, Columbia Presbyterian Medical Center

	2003	Grand Rounds: The Pathogenesis of Primary Open-Angle Glaucoma, Mt Sinai Hospital, New York, NY

	2005	Grand Rounds: Glaucoma: Difficult Cases, Difficult Choices, New York Presbyterian Hospital

	Visiting Professorship

	2004	Case Presentations, Wills Eye Hospital, Philadelphia, PA

3. Description of Teaching Award(s) Received

	1995	Harvard Medical School Award for Mentoring; Nominee Harvard Medical School
	2003	Recognition for outstanding teaching and commitment to education by ophthalmology residency members. Massachusetts Eye and Ear Infirmary

4. Description of major curriculum offerings, teaching cases or innovative educational programs developed

2004

Teaching Cases
I developed a 5-module, online teaching program directed to primary care providers. Each module addresses a specific red eye case. The cases consist of orginal material with interactive question and answer sections to make teaching points

E. Report of Clinical Activities

1996-

Glaucoma, Massachusetts Eye and Ear Infirmary
Clinical Activity Description: 100 outpatient visits per week 12-15 surgical procedures per month
Patient Load: 100/week; high

Part III: Bibliography

Original Articles

1.	DiToro DM, Mahony J, Kirchgraber P, O'Byrne AL, Pasquale LR, Piccirilli D. Effects of nonreversibility, particle concentration and ionic strength on heavy metal sorption. Env Sci & Tech. 1986;20:55-61.
2.	Pasquale L, Winiski A, Oliva C, Vaio G, McLaughlin S. An experimental test of new theoretical models for the electrokinetic properties of biological membranes. The effect of UO2++ and tetracaine on the electrophoretic mobility of bilayer membranes and human erythrocytes. J Gen Physiol. 1986;88(6):697-718.
3.	Pasquale LR, Moster ML, Schmaier A. Dural sinus thrombosis with abnormalities of protein S and fibrinogen. Arch Ophthalmol. 1990;108:644.
4.	Pasquale LR, Mathias RT, Austin LR, Brink PR, Ciunga M. Electrostatic properties of fiber cell membranes from the frog lens. Biophys J. 1990;58(4):939-45.
5.	Pasquale LR, Romayananda N, Kubacki J, Johnson MH, Chan GH. Congenital cystic eye with multiple ocular and intracranial anomalies. Arch Ophthalmol. 1991;109(7):985-7.
6.	Pasquale LR, Smith SG, Traboulsi E, Jampel H. Spontaneous filtration blebs in a patient with microspherophakia. Am J Ophthalmol. 1991;112(3):350-2.
7.	Derick RJ, Pasquale L, Quigley HA, Jampel H. Potential toxicity of mitomycin C. Arch Ophthalmol. 1991;109(12):1635.
8.	Pasquale LR, Thibault D, Dorman-Pease ME, Quigley HA, Jampel HD. Effect of topical mitomycin C on glaucoma filtration surgery in monkeys. Ophthalmology. 1992;99(1):14-8.
9.	Pasquale LR, Smith SG. Surgical outcome of phacoemulsification combined with the Pearce trabeculectomy in patients with glaucoma. J Cataract Refract Surg. 1992;18(3):301-5.
10.	Jampel HD, Pasquale LR, Dibernardo C. Hypotony maculopathy following trabeculectomy with mitomycin C. Arch Ophthalmol. 1992;110(8):1049-50.
11.	Pasquale LR, Dorman-Pease ME, Lutty GA, Quigley HA, Jampel HD. Immunolocalization of TGF-beta 1, TGF-beta 2, and TGF-beta 3 in the anterior segment of the human eye. Invest Ophthalmol Vis Sci. 1993;34(1):23-30.
12.	Derick RJ, Pasquale LR, Pease ME, Quigley HA. A clinical study of peripapillary crescents of the optic disc in chronic experimental glaucoma in monkey eyes. Arch Ophthalmol. 1994;112(6):846-50.
13.	Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994;331(22):1480-7.
14.	Nordlund JR, Pasquale LR, Robin AL, Rudikoff MT, Ordman J, Chen KS, Walt J. The cardiovascular, pulmonary, and ocular hypotensive effects of 0.2% brimonidine. Arch Ophthalmol. 1995;113(1):77-83.
15.	VanderVeen DK, Pasquale LR, Fulton AB. Central retinal vein occlusion in a young child with cyanotic heart disease. Arch Ophthalmol. 1997;115(8):1077.
16.	Migdal C, Perkins TW, Pasquale L. Management of chronic choroidal effusions. J Glaucoma. 1999;8(5):325-7.
17.	Gasch AT, Wang P, Pasquale LR. Determinants of glaucoma awareness in a general eye clinic. Ophthalmology. 2000;107(2):303-8.
18.	Bohn RL, Gurwitz JH, Yeomans SM, Glynn RJ, Pasquale LR, Walker AM, Avorn J. Which patients are treated for glaucoma? An observational analysis. J Glaucoma. 2000;9(1):38-44.
19.	Chen TC, Ang RT, Grosskreutz CL, Pasquale LR, Fan JT. Brimonidine 0.2% versus apraclonidine 0.5% for prevention of intraocular pressure elevations after anterior segment laser surgery. Ophthalmology. 2001;108(6):1033-8.
20.	Sankar PS, Pasquale LR, Grosskreutz CL. Uveal effusion and secondary angle-closure glaucoma associated with topiramate use. Arch Ophthalmol. 2001;119(8):1210-1.
21.	Kang JH, Pasquale LR, Rosner B, Willet W, Egan KM, Faberowski N, Hankinson SE. Prospective study of cigarette smoking and the risk of primary open-angle glaucoma. Arch Ophthalmol. 2003;121:1762-68.
22.	Kang JH, Pasquale LR, Rosner B, Willet W, Faberowski N, Hankinson SE. Prospective study of antioxidant intake and the risk of primary open-angle glaucoma in two cohorts. Am Journal of Epidemiology. 2003;158:337-346.
23.	Fay A, Lee LC, Pasquale LR. Dermatochalasis causing apparent bitemporal hemianopsia. Ophthal Plast Reconstr Surg. 2003;19(2):151-3.
24.	Banks MC, Robe-Collignon NJ, Rizzo JF, Pasquale LR. Scanning laser polarimetry of edematous and atrophic optic nerve heads. Arch Ophthalmol. 2003;121(4):484-90.
25.	Kang JH, Pasquale LR, Willett W, Rosner B, Egan KM, Faberowski N, Hankinson SE. Antioxidant intake and primary open-angle glaucoma: a prospective study. Am J Epidemiol. 2003;158(4):337-46.
26.	Kang JH, Pasquale LR, Willett WC, Rosner BA, Egan KM, Faberowski N, Hankinson SE. Dietary fat consumption and primary open-angle glaucoma. Am J Clin Nutr. 2004;79(5):755-64.
27.	Zhao JC, Zacks DN, Gragoudas ES, Pasquale LR. Pupil sparing excision of an atypical iris melanocytoma induces remission of secondary glaucoma. Br J Ophthalmol. 2004;88(6):842-3.
28.	Geiser DK, Williams RT, O’Connell W, Dul M, Pasquale LR, Watt JG, Katz LM, Siegartel LR, Wang L, Stern LS, Doyle JJ. Cost and utilization of end-stage glaucoma patients receiving low vision rehabilitation care: A U.S. multi-site retrospective study. J Glaucoma (submitted). 2005.
29.	Brauner SC, Chen TC, Chang MA, Pasquale LR, Grosskreutz CL. Glaucoma during pregnancy. Ophthalmology (submitted). 2005.
30.	Pasquale LR, Brusie S, Pahk P, Fine L, Grosskreutz CL, Chen T, Winkelmeyer W. The blue arc phenomenon in glaucoma. Br J Ophthalmol (in preparation). 2005.

Reviews/Chapters/Editorials

1.	Pasquale LR, Green WR. Exfoliation syndrome: slit lamp biomicroscopy and pathological findings of the anterior segment. New Trends in Ophthalmology. 1993;8:117-129.
2.	Ayaki M, Pasquale LR. Glaucoma laser surgery. Ophthalmology (Tokyo). 1995;37:995-997.
3.	Pasquale LR. Graft-versus-host-desease and dry eyes. Bone Marrow Transplant Support Group Newsletter. 1995;4(3).
4.	Pasquale LR. Update on Alpha-2 adrenergic agonists. Review of Ophthalmology. 1995;2:99-100.
5.	Chen TC, Pasquale LR, Walton DS, Grosskreutz CL. Diode laser transscleral cyclophotocoagulation. Int Ophthalmol Clin. 1999;39(1):169-76.
6.	Leuenberger EU, Grosskreutz CL, Walton DS, Pasquale LR. Advances in aqueous shunting procedures. Int Ophthalmol Clin. 1999;39(1):139-53.
7.	Gasch AT, Foster CS, Grosskreutz CL, Pasquale LR. Postoperative sympathetic ophthalmia. Int Ophthalmol Clin. 2000;40(1):69-84.
8.	Pasquale LR. Neuroprotection in glaucoma 2000: Do vitamins reduce the risk of developing primary open-angle glaucoma? Boston: Ophthalmology Interactive. 2000:CD-ROM.
9.	Bahabur G, Choplin NT, Lytle RA, Pasquale LR, Sliverstone DE, Higginbotham EJ. Advances in glaucoma diagnosis: Objective detection technology. Ocula Surgery News. 2000.
10.	Pasquale, LR. Glaucoma the requisites in ophthalmology by Alward AWL. Am J Ophthalmol. 2001;131:682-3.
11.	Lee LC, Pasquale LR. Surgical management of glaucoma in pseudophakic patients. Seminars in Ophthalmology. 2002;17:131-137.
12.	Pasquale LR. Glaucoma Surgery: Past, Present, and Future. Vision and Aging. 2002;2:16-19.
13.	Sankar PS, Chen TC, Grosskreutz CL, Pasquale LR. Traumatic hyphema. Int Ophthalmol Clin. 2002;42(3):57-68.
14.	Pasquale LR. Glaucoma specialty clinical update: neovascular glaucoma. American Academy of Ophthalmology. 2002.
15.	Pasquale LR. Glaucoma specialty clinical update: primary open-angle glaucoma. American Academy of Ophthalmology. 2002.
16.	Maw R, Pineda R, Pasquale LR, Dana MR. Traumatic ruptured globe injuries in children. Int Ophthalmol Clin. 2002;42(3):157-65.
17.	Lee LC, Pasquale LR. Surgical management of glaucoma in pseudophakic patients. Semin Ophthalmol. 2002;17(3-4):131-7.
18.	Halpern DL, Pasquale LR. Cystoid macular edema in aphakia and pseudophakia after use of prostaglandin analogs. Semin Ophthalmol. 2002;17(3-4):181-6.
19.