Makino Publications


Makino, C.L., Wen, X.-H., Olshevskaya, E.V., Peshenko, I.V., Savchenko, A.B. and Dizhoor, A.M. (2012). Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice. PLoS ONE 7: e47637.

Makino, C.L., Wen, X.-H., Michaud, N.A., Covington, H.I., DiBenedetto, E., Hamm, H.E., Lem, J. and Caruso, G. (2012). Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics. PLoS ONE 7: e37832.

Wen, X.-H., Duda, T., Pertzev, A., Venkataraman, V., Makino, C.L. and Sharma, R.K. (2012). S100B serves as a Ca2+ sensor for ROS-GC1 guanylate cyclase in cones but not in rods of the murine retina. Cellular Physiology and Biochemistry 29: 417-430.

Miyazono, S., Isayama, T., DeLori, F.C. and Makino, C.L. (2011). Vitamin A activates rhodopsin and sensitizes it to UV light. Visual Neuroscience 28: 485-497.

Makino, C.L., Riley, C.K., Looney, J., Crouch, R.K. and Okada, T. (2010). Binding of more than one retinoid to opsins. Biophysical Journal 99: 2366-2373.

Liu, X., Pawlyk, B.S., Adamian, M., Olshevskaya, E.V., Dizhoor, A.M., Makino, C.L. and Li, T. (2009). Increased light exposure alleviates one form of photoreceptor degeneration marked by elevated calcium in the dark. PLoS ONE 4: e8438.

Isayama, T., McCabe, England S.L., Crouch, R.K., Zimmerman, A.L. and Makino, C.L. (2009). Beta-ionone activates and bleaches visual pigment in salamander photoreceptors. Visual Neuroscience 26: 267-274.

Wen, X.-H., Shen, L., Brush, R.S., Michaud, N., Al-Ubaidi, M.R., Gurevich, V.V., Hamm, H.E., Lem, J., DiBenedetto, E., Anderson, R.E. and Makino, C.L. (2009). Over-expression of rhodopsin alters the structure and photoresponse of rod photoreceptors. Biophysical Journal 96: 939-950.

Makino, C.L., Peshenko, I.V., Wen, X.-H., Olshevskaya, E.V., Barrett, R. and Dizhoor, A.M. (2008). A role for GCAP2 in regulating the photoresponse: guanylyl cyclase activation and rod electrophysiology in GUCA1B knockout mice. Journal of Biological Chemistry 283: 29135-29143.

Yang, J., Pawlyk, B., Wen, X.-H., Adamian, M., Soloviev, M., Michaud, N., Zhao, Y., Sandberg, M.A., Makino, C.L. and Li. T. (2007). Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals. Human Molecular Genetics 16:1017-1029.

Isayama, T., Chen, Y., Kono, M., DeGrip, W.J., Ma, J.-X., Crouch, R.K. and Makino, C.L. (2006). Differences in the pharmacological activation of visual opsins. Visual Neuroscience 23: 899-908.

Isayama, T., Alexeev, D., Makino, C.L., Washington, I., Nakanishi, K. and Turro, N.J. (2006). An accessory chromophore in red vision. Nature 443: 649.

He, Q., Alexeev, D., Estevez, M.E., McCabe, S.L., Calvert, P.D., Ong, D.E., Cornwall, M.C., Zimmerman, A.L. and Makino, C.L. (2006). Cyclic nucleotide-gated ion channels in rod photoreceptors are protected from retinoid inhibition. Journal of General Physiology 128: 473-485.

Makino, C.L., Wen, X.-H., Michaud, N., Peshenko, I.V., Pawlyk, B., Brush, R.S., Solovyeva, M., Liu, X., Woodruff, M.L., Calvert, P.D., Savchenko, A.B., Anderson, R.E., Fain, G.L., Li, T., Sandberg, M.A. and Dizhoor, A.M. (2006). Effects of low AIPL1 expression on phototransduction in rods. Investigative Ophthalmology and Visual Science 47: 2185-2194.

Wang, Z., Wen, X.-H., Ablonczy, Z., Crouch, R.K., Makino, C.L. and Lem, J. (2005). Enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation-deficient rhodopsin. Journal of Biological Chemistry 280: 24293-24300.

Yang, J., Gao, J., Adamian, M., Wen, X.-H., Pawlyk, B., Zhang, L., Sanderson, M.J., Zuo, J., Makino, C.L. and Li, T. (2005). The ciliary rootlet maintains long-term stability of sensory cilia. Molecular and Cellular Biology 25: 4129-4137.

Liu, X., Bulgakov, O., Wen, X.-H., Woodruff, M.L., Pawlyk, B., Yang, J., Fain, G.L., Sandberg, M., Makino, C.L. and Li, T. (2004). AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase. Proceedings of the National Academy of Sciences of the USA 101: 13903-13908.

Olshevskaya, E.V., Calvert, P.D., Woodruff, M.L., Peshenko, I.V., Savchenko, A.B., Makino, C.L., Ho, Y.-S., Fain, G.L. and Dizhoor, A.M. (2004). Y99C GCAP1 increases intracellular Ca2+ and causes photoreceptor degeneration in transgenic mice. Journal of Neuroscience 24: 6078-6085.

Makino, C.L., Dodd, R.L., Chen, J., Burns, M.E., Roca, A., Simon, M.I. and Baylor, D.A. (2004). Recoverin regulates light-dependent phosphodiesterase activity in retinal rods. Journal of General Physiology 123: 729-741.

Makino, C.L., Wen, X.-H. and Lem, J. (2003). Piecing together the timetable for visual transduction with transgenic animals. Current Opinion in Neurobiology 13: 404-412.

Calvert, P.D., Govardovskii, V.I., Arshavsky, V.Y. and Makino, C.L. (2002). Two temporal phases of light adaptation in retinal rods. Journal of General Physiology 119: 129-145.

Ma, J.-X., Znoiko, S., Otherson, K.L., Ryan, J.C., Das, J., Isayama, T., Kono, M., Oprian, D.D., Corson, D.W., Cornwall, M.C., Cameron, D.A., Harosi, F.I., Makino, C.L. and Crouch, R.K. (2001). A visual pigment expressed in both rod and cone photoreceptors. Neuron 32: 451-461.

Sieving, P.A., Fowler, M.L., Bush, R.A., Machida, S., Calvert, P.D., Green, D.G., Makino, C.L. and McHenry, C. (2001). Constitutive “light” adaptation in rods from G90D rhodopsin: a mechanism for human congenital stationary night blindness without rod cell loss. Journal of Neuroscience 21: 5449-5460.

Calvert, P.D., Govardovskii, V.I., Krasnoperova, N., Anderson, R.E., Lem, J. and Makino, C.L. (2001). Membrane protein diffusion sets the speed of rod phototransduction. Nature 411: 90-94.

Calvert, P.D., Krasnoperova, N.V., Lyubarsky, A.L., Isayama, T., Nicolo, M., Kosaras, B., Wong, G., Gannon, K.S., Margolskee, R.F., Sidman, R.L., Pugh, E.N. Jr., Makino, C.L. and Lem, J. (2000). Phototransduction in transgenic mice after targeted deletion of the rod transducin a-subunit. Proceedings of the National Academy of Sciences of the USA 97: 13913-13918.

Makino, C.L., Groesbeek, M., Lugtenburg, J. and Baylor, D.A. (1999). Spectral tuning in salamander visual pigments studied with dihydroretinal chromophores. Biophysical Journal 77: 1024-1035.

Lem, J., Krasnoperova, N.V., Calvert, P.D., Kosaras, B., Cameron, D.A., Nicolo, M., Makino, C.L. and Sidman, R.L. (1999). Morphological, physiological and biochemical changes in rhodopsin knockout mice. Proceedings of the National Academy of Sciences of the USA 96: 736-741.

Xu, J., Dodd, R.L., Makino, C.L., Simon, M.I., Baylor, D.A. and Chen, J. (1997). Prolonged photoresponses in transgenic mouse rods lacking arrestin. Nature 389: 505-509.

Lem, J. and Makino, C.L. (1996). Phototransduction in transgenic mice. Current Opinion in Neurobiology 6: 453-458.

Makino, C.L. and Dodd, R.L. (1996). Multiple visual pigments in a photoreceptor of the salamander retina. Journal of General Physiology 108: 27-34.

Chen, J., Makino, C.L., Peachey, N.S., Baylor, D.A. and Simon, M.I. (1995). Mechanisms of rhodopsin inactivation in vivo as revealed by a COOH-terminal truncation mutant. Science 267: 374-377.

Raport, C.J., Lem, J., Makino, C., Chen, C.-K., Hobson, A., Baylor, D., Simon M.I. and Hurley, J.B. (1994). Down-regulation of cGMP phosphodiesterase induced by expression of a GTPase-deficient cone transducin in mouse rod photoreceptors. Investigative Ophthalmology and Visual Science 35: 2932-2947.

Sung, C.-H., Makino, C., Baylor, D. and Nathans, J. (1994). A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment. Journal of Neuroscience 14: 5818-5833.

Kraft, T.W., Makino, C.L., Mathies, R.A., Lugtenburg, J., Schnapf, J.L. and Baylor, D.A. (1991). Cone excitations and color vision. Cold Spring Harbor Symposia on Quantitative Biology 50: 635-641.

Makino, C.L., Taylor, W.R. and Baylor, D.A. (1991). Rapid charge movements and photosensitivity of visual pigments in salamander rods and cones. Journal of Physiology 442: 761-780.

Makino, C.L., Howard, L.N. and Williams, T.P. (1990). Axial gradients of rhodopsin in light-exposed retinal rods of the toad. Journal of General Physiology 96: 1199-1220.

Makino, C.L., Kraft, T.W., Mathies, R.A., Lugtenburg, J., Miley, M.E., van der Steen, R. and Baylor, D.A. (1990). Effects of modified chromophores on the spectral sensitivity of salamander, squirrel and macaque cones. Journal of Physiology 424: 545-560.

Williams, T.P., Penn, J.S., Bush, R.A. and Makino, C.L. (1988). Renewal of rod outer segment and regulation of daily photon catch by the rat retina. Proceedings of the Yamada Conference XXI: 255-260.

Makino, C.L., Howard, L.N. and Williams, T.P. (1987). Intracellular topography of rhodopsin bleaching. Science 238: 1716-1717.

Thompson, J.M., Makino, C.L., Whitaker, J.R. and Joseph, J.A. (1984). Age-related decrease in apomorphine modulation of acetylcholine release from rat striatal slices. Brain Research 299: 169-173.

Schiffman, S.S., Lindley, M.G., Clark, T.B. and Makino, C.L. (1981). Molecular mechanism of sweet taste: relationship of hydrogen bonding to taste sensitivity for both young and elderly. Neurobiology of Aging 2: 173-185.


Isayama, T. and Makino, C.L. (2012). Pigment mixtures and other determinants of spectral sensitivity of vertebrate retinal photoreceptors, in Photoreceptors: Physiology, Types and Abnormalities, eds. E. Akutagawa and K Ozaki. Nova Science Publishers, pp. 1-31.

MacLeish, P.R. and Makino, C.L. (2011). Photoresponses of rods and cones, in Adler’s Physiology of the Eye, eds. L.A. Levin, S.F.E. Nilsson, J. Ver Hoeve, S.M. Wu, P.L. Kaufman and A. Alm. Elsevier Inc., pp. 411-428.

Bush, R.A. and Makino, C.L. (2006). Recoverin shapes the photoresponse of retinal rods, in Neuronal Calcium Sensors, eds. K.-W. Koch and P.P. Philippov. Nova Scientific, pp. 153-180.

Calvert, P.D. and Makino, C.L. (2002). The time course of light adaptation in vertebrate retinal rods, in Photoreceptors and Calcium, eds. W. Baehr and K. Palczewski. Kluwer Academic/Plenum Publishers and Landes Bioscience, New York, pp. 37-60.

Roof, D.J. and Makino, C.L. (2000). The structure and function of retinal photoreceptors, in Principles and Practice of Ophthalmology 2nd edition, eds. F.A. Jakobiec and D.M. Alberts. W.B. Saunders Co., Philadelphia, pp. 1624-1673.

Makino, C.L., Flannery, J.G., Chen, J. and Dodd, R.L. (1998). Effects of photoresponse prolongation on retinal rods of transgenic mice, in Photostasis, eds. T.P. Williams and A.S. Thistle. Plenum Publishing Corp, NY. pp. 129-151.


Makino, C.L. (2012). Easy does it when bleaching isolated mouse rods. Journal of Physiology 590: 2551-2552.


Isayama, T., Zimmerman, A.L. and Makino, C.L. (2009). The molecular design of visual transduction. Biophysical Society