HARVARD-VISION Clinical Scientist Development Program (K12)


clinician scientist

Summary. The Harvard Department of Ophthalmology is one of the leading and largest academic departments of Ophthalmology in the nation and a major recipient of NIH funding. With nearly 150 full-time clinical and basic science faculty, it continues to make significant contributions to ophthalmic and vision research in virtually all basic, applied, and clinical subspecialty areas. The Harvard-Vision Clinical Scientist Development Program proposes to offer a customized and structured learning, research, and development environment to a select group of qualified clinically trained candidates who have recently completed (or about to complete) their training, but who desire further mentored learning experience so as to become independent leading clinical scientists in their respective fields. Trainees in this program will (i) complete a core curriculum that will include the Harvard Program in Clinical Effectiveness (PCE) – a summer-long immersion program in biostatistics, epidemiology, study design, and outcomes measurement. Additional required curricular activities will include the Harvard Medical School course, HBTM 303qc “Introduction to the Visual System”, a multidisciplinary survey course focusing on the biological mechanisms (genetics, immunology, neuroscience, vascular biology) of eye disease. Candidates will also (ii) perform research in a closely mentored program under the guidance of lead mentors who are leaders in their respective fields with the express objective of allowing them to develop into independent investigators. Trainees in this program will additionally have the option of seeking an advanced degree (MS, MPH, PhD, ScD) at Harvard.

Background. The extraordinary growth and specialization that has occurred over the past several decades in the sciences has made it increasingly difficult to link the increasing divide between clinical and basic science components of ophthalmic and vision sciences. The less-than-optimal degree of cross-talk between scientists engaged in studying fundamental biological processes and clinicians providing care to patients has had multiple deleterious effects. Continued external factors are expected to impact this trend negatively for the foreseeable future. Traditional approaches, based purely on didactic curricula, to “teach” basic sciences to highly trained clinicians are only variably effective as they offer limited opportunity to these clinicians for hands-on experience in designing and conducting studies. Additionally, many clinicians engaged in pure clinical (vs. bench-based) research have had very limited formal training in methodological aspects of clinical study design and execution.

To address these needs the Harvard-Vision Clinical Scientist Development Program is seeking to recruit and train clinician-scientists as detailed below.

We are seeking subspecialty/fellowship-trained board-certified/eligible ophthalmologists (or optometrists) to commit, at the level of Junior Faculty with 75% of their time dedicated to structured research (up to 25% clinical work) and the development program under mentorship of one of our senior faculty. The duration of commitment will be 3-5 years based on the interests of the candidate and the nature of the mentored training program.

A position is available throughout the Harvard Ophthalmology system for July 1 of the next academic year.

Interested applicants should contact Cori O’Brien at 617-573-3311 or cori_o’brien@meei.harvard.edu for an application. Applicants should also identify a mentor within the Harvard faculty or MIT community and contact them to discuss potential mentor relationship if accepted into the program.

In addition please submit (1) a complete curriculum vitae, (2) 1-2 page letter of intent describing how this mechanism will further your career in vision science, (4) 1-2 page Scientific Proposal (4) 3 letters of recommendation to Reza Dana, MD, MPH c/o Cori O’Brien Massachusetts Eye and Ear 243 Charles St, Boston, MA 02114. US citizenship or resident alien status (green card) is required for acceptance to the program.

Application deadline is December 15 for the following July 1.

This program is funded by the National Institutes of Health. We are an Equal Opportunity/Affirmative Action Employer. Women & Minorities are encouraged to apply.

Scope of Research and List of Mentors

Below, are tables listing the ophthalmic subspecialty areas, and academic disciplines and related faculty, offered through the Harvard-Vision Clinical Scientist Development Program.

Institution Key

BWH

Brigham & Women’s Hospital

Children’s

Boston Children’s Hospital

HMS

Harvard Medical School

HSPH

Harvard School of Public Health

HU

Harvard University

JDC

Joslin Diabetes Center

MEEI

Massachusetts Eye and Ear

MGH

Massachusetts General Hospital

SERI

Schepens Eye Research Institute of Mass. Eye and Ear

Table 1. Subspecialty Areas - Harvard-Vision Clinical Scientist Development Program

Ocular Area of Concentration

Mentors & Faculty

(may be listed in >1 area of expertise)

Institution

Cornea & Anterior Segment

Pablo Argüeso, PhD

Reza Dana, MD, MSc, MPH

Darlene Dartt, PhD

Ilene Gipson, PhD

Ula Jurkunas, MD

James Zieske, PhD

SERI

MEEI & SERI

SERI

SERI

SERI

SERI

Glaucoma

Louis Pasquale, MD

Janey L. Wiggs, MD, PhD

MEEI

MEEI

Inherited Retinopathies

Eliot Berson, MD

Eric Pierce, MD, PhD

MEEI

MEEI

Low Vision

Alex Bowers, PhD

Eli Peli, OD

David G. Hunter, MD (pediatric)

SERI

SERI

Children’s

Macular Degeneration

Dean Eliott, MD

Evangelos Gragoudas, MD

Joan Miller, MD

MEEI

MEEI

MEEI

Nutrition & Disease

Susan Hankinson, ScD, MPH

Debra Schaumberg, ScD, MPH

HMS

BWH

Ocular Inflammation & Microbiology

James Chodosh, MD

Reza Dana, MD, MSc, MPH

Michael Gilmore, PhD

MEEI

MEEI & SERI

MEEI

Ocular Oncology

Evangelos Gragoudas, MD

MEEI

Pediatric Ophthalmology

David G. Hunter, MD

Children’s

Proliferative Vitreoretinopathy

Lloyd Paul Aiello, MD, PhD

Robert D’Amato, MD, PhD

Patricia D’Amore, PhD

Andrius Kazlauskas, PhD

Mara Lorenzi, MD

Joan Miller, MD

Lois Smith, MD, PhD

JDC

Children’s & MEEI

SERI

SERI

SERI & MGH

MEEI

Children’s

Retinal Physiology & Development

Larry Benowitz, PhD

Connie Cepko, PhD

John Dowling, PhD

Richard Masland, PhD

Children’s

HMS

HU, Biological Labs

MEEI

Tear Film & Ocular Surface

Reza Dana, MD, MSc, MPH

Darlene Dartt, PhD

Ilene Gipson, PhD

David Sullivan, PhD

James Zieske, PhD

SERI

SERI

SERI

SERI

SERI

Table 2. Academic Disciplines - Harvard-Vision Clinical Scientist Development Program

Academic Discipline

Mentors & Faculty

(may be listed in >1 area of expertise)

Institution

Biostatistics & Epidemiology

Robert Glynn, ScD

Susan Hankinson, ScD, MPH

Louis Pasquale, MD

Debra Schaumberg, ScD, MPH

Meir Stampfer, MD, DrPH

BWH

HMS

MEEI

BWH

HSPH

Cell Biology

Ilene Gipson, PhD

Ula Jurkunas, MD

Andrius Kazlauskas, PhD

James Zieske, PhD

SERI

SERI

SERI

SERI

Clinical Trials

Francis Cook, ScD, MS

Dean Eliott, MD

Robert Glynn, ScD

Evangelos Gragoudas, MD

Joan Miller, MD

Louis Pasquale, MD

Debra Schaumberg, MSc, MPH

HMS, Clin. Effect. Prog.

MEEI

BWH

MEEI

MEEI

MEEI

BWH

Development

John Dowling, PhD

HMS, Biological Labs

Genetics

Eliot Berson, MD

Connie Cepko

Eric Pierce, MD, PhD

Janey Wiggs, MD, PhD

MEEI

HMS

MEEI

MEEI

Immunology & Microbiology

Pablo Argüeso, PhD

James Chodosh, MD

Reza Dana, MD, MSc, MPH

Michael Gilmore, PhD

SERI

MEEI

MEEI & SERI

MEEI

Matrix Remodeling & Angiogenesis

Lloyd Paul Aiello, MD, PhD

Patricia D’Amore, PhD

Reza Dana, MD, MSc, MPH

Joan Miller, MD

JDC

SERI

MEEI & SERI

MEEI

Neurobiology

Larry Benowitz, PhD

John Dowling, PhD

Richard Masland, PhD

Children’s

HMS, Biological Labs

MEEI

Optics

Alex Bowers, PhD

Eli Peli, OD

SERI

SERI

Physiology

Darlene Dartt, PhD

Ilene Gipson, PhD

David Hunter, MD, PhD

David Sullivan, PhD

James Zieske, PhD

SERI

SERI

Children’s

SERI

SERI

Vascular & Endothelial Biology

Lloyd Paul Aiello, MD, PhD

Patricia D’Amore, PhD

Mara Lorenzi, MD

Lois Smith, MD, PhD

JDC

SERI

SERI & MGH

Children’s